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Notice

10 March 2020. Due to the ongoing COVID-19 pandemic, Europe is on lockdown. This also affects the ACDC and its continuous work on the project. As universities and labs are closed, almost all the ACDC experiments are interrupted. We are taking steps to try to minimize our activity disruption, while ensuring the safety and wellbeing of our researchers and the people with whom they work. Our researchers are now working remotely and are doing their best to keep non-experimental activities going and stay connected and responsive to a prompt restart. In the meantime, some of us are also putting their expertise at the service of the community for fighting the infection; we're proud of them. Please check the news for details and updates.

ACDC Project

Artificial Cells with Distributed Cores

ACDC Project

Artificial Cells with Distributed Cores

Our Goals

Responsive Architecture

To construct responsive architectures and metabolism based on living cells and tissues

Programmable processes

To build programmable and re-configurable, (bio)chemical processes

Microscaling

Enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication

Miniaturization

To exploit the miniaturization provided by lab on a chip technology

ACDC envisions a future where ‘chemical apps’ on mobile personal devices produce on demand valuable compounds for health and performance as well as apps for bioagent threat detection and disease. To take concrete and defined steps toward this future vision, we will exploit the miniaturization provided by lab on a chip technology and construct responsive architectures and metabolism based on living cells and tissues. We will build programmable and re-configurable, (bio)chemical processes, with precision, order, and as hierarchical cellular constructs, modelled after living systems. We will enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication, just as one finds in organelles, cells and tissues.

Work Packages

WP1

This work package is dedicated to implement the design, functional verification by mathematical modelling, and fabrication using novel, multi-material 3D-printing, of increasingly complex fluidic structures, to realise, lipid-bound, multicore droplets of a selected architecture.

WP2

This work package is dedicated to make labelled cores that can be assembled and disassembled based on programmable DNA sequence information and environmental conditions.

WP3

This work package is dedicated to develop core-core and capsule-capsule communication through membrane pores and molecule-mediated transport.

WP4

This work package is dedicated to develop of a modelling framework for in silico design.

WP5

This work package is dedicated to exploiting ACDC cores towards applications such as receptor-ligand screening and low molecular weight compound screening.

WP6

This work package aims to strengthen an inclusive communication approach among researchers, third sector organizations, learners and lay people, through participatory strategies starting in the early stages of the ACDC research development.

WP7

This work package provides administrative, technical and scientific management of the project to ensures that the scientific and technical milestones and deliverables are achieved.

Partners

Who is contributing to the project.

UNIVERSITY OF CARDIFF

EXPLORA BIOTECH

MUSE

ELVESYS

University of Trento

Zurich University of Applied Sciences

The Last Event

ACDC Meeting at Cardiff, 2-3 July 2019.

2-3 July 2019

Last July all the ACDC members met at Cardiff for a project meeting. During the meeting, the members got training in PI rights, visited the Cardiff premises and worked together to establish the progress of the action and the specifics of the research to be done in the next 6 months.

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