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ACDC Project

Artificial Cells with Distributed Cores

ACDC Project

Artificial Cells with Distributed Cores

Our Goals

Responsive Architecture

To construct responsive architectures and metabolism based on living cells and tissues

Programmable processes

To build programmable and re-configurable, (bio)chemical processes

Microscaling

Enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication

Miniaturization

To exploit the miniaturization provided by lab on a chip technology

ACDC envisions a future where ‘chemical apps’ on mobile personal devices produce on demand valuable compounds for health and performance as well as apps for bioagent threat detection and disease. To take concrete and defined steps toward this future vision, we will exploit the miniaturization provided by lab on a chip technology and construct responsive architectures and metabolism based on living cells and tissues. We will build programmable and re-configurable, (bio)chemical processes, with precision, order, and as hierarchical cellular constructs, modelled after living systems. We will enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication, just as one finds in organelles, cells and tissues.

Work Packages

WP1

This work package is dedicated to implement the design, functional verification by mathematical modelling, and fabrication using novel, multi-material 3D-printing, of increasingly complex fluidic structures, to realise, lipid-bound, multicore droplets of a selected architecture.

WP2

This work package is dedicated to make labelled cores that can be assembled and disassembled based on programmable DNA sequence information and environmental conditions.

WP3

This work package is dedicated to develop core-core and capsule-capsule communication through membrane pores and molecule-mediated transport.

WP4

This work package is dedicated to develop of a modelling framework for in silico design.

WP5

This work package is dedicated to exploiting ACDC cores towards applications such as receptor-ligand screening and low molecular weight compound screening.

WP6

This work package aims to strengthen an inclusive communication approach among researchers, third sector organizations, learners and lay people, through participatory strategies starting in the early stages of the ACDC research development.

WP7

This work package provides administrative, technical and scientific management of the project to ensures that the scientific and technical milestones and deliverables are achieved.